August 17, 2020
Looking for a method to deplete long non-coding RNAs (lincRNAs)? Alex wrote up a detailed protocol on how to use self-cleaving Ribozymes to specifically deplete lincRNA transcripts. Tuck A.C., Bühler M. (2021) Long Non-coding RNA Depletion Using Self-Cleaving Ribozymes. Methods in Molecular Biology.
June 9, 2020
Fed up with manual yeast colony counting? Here is the solution: Carl SH, Duempelmann L, Shimada Y, Bühler M. A fully automated deep learning pipeline for high-throughput colony segmentation and classification. 2020. Biol open.
May 20, 2020
Claudia Keller Valsecchi, a former PhD student of the Bühler lab, just started her own group at the IMB in Mainz. Check it out!
March 20, 2020
Today at 2pm Lea Duempelmann is defending her thesis but due to the current situation, sadly no audience is allowed. Therefore the defense talk will be streamed live via zoom and everybody interested can join in!
Topic: Inheritance of a phenotypically plastic epimutation
Zoom link: https://zoom.us/j/716618113
Meeting ID: 716 618 113
Good luck, Lea!
February 27, 2020
Today was Aude’s last day after successfully defending her master thesis. All the best for your future and take care!
February 11, 2020
Alex and Aneliya’s paper on the interplay of RNA decay, RNA surveillance and translation is out now! Have a look here: Tuck AC*, Rankova A*, Arpat AB, Liechti LA, Hess D, Iesmantavicius V, Castelo-Szekely V, Gatfield D and Bühler M. Mammalian RNA decay pathways are highly specialized and widely linked to translation. 2020. Molecular Cell.
January 20, 2020
Want to learn more about where and how small RNAs are implicated in transgenerational epigenetic inheritance? Have a look at the review article by Lea and Merle that just came out.
October 14, 2019
Try our automated deep learning pipeline for yeast colony color classification. It speeds up white/red color quantification by 100-fold with very high accuracy, compared to manual counting by an experienced biologist. Any feedback or suggestions are welcome!
September 18-20, 2019
FMI annual meeting . We just spent three awesome days of science and mountaineering in Grindelwald.
Congrats to Alex, he received the Max Burger price for the best Postdoc paper in 2018!!!
September 5, 2019
New paper out in Cell on the role of the ChAHP (CHD4-ADNP-HP1) complex in 3D genome architecture and safe-guarding the genome against unwanted rewiring upon SINE-mediated CTCF motif expansions. Kaaij, Mohn et al. Cell, 2019.
August 18, 2019
New paper out in Genes & Development. Alex Tuck and Thomas Welte elucidated in a collaborative effort between the Bühler and Grosshans labs the role of the RNA binding protein Trim71 in normal and deseased states. Welte, Tuck et al., Genes Dev., 2019.
March 27, 2019
New lab paper published in Molecular Cell! Duempelmann et al find an epimutation that is transmitted over generations without notable phenotype but will result in gene silencing when the Paf1 complex is mutated.
March 27, 2019
Finally it is time to get back to the bench after a sunny and powdery winter break 🙂 !
October 11, 2018
Our former PhD student Valentin Flury, together with Sivia Domcke, received this years Ed Fisher price awarded for the best thesis in 2017. Congrats!
September 19, 2018
September 17, 2018
We welcome Merle Skribbe! Merle will conduct her masters thesis work in our lab. Good luck!
August 1, 2018
New lab paper comprehensively characterizing mouse lincRNAs is now online at Life Science Alliance. Tuck et al, “Distinctive features of lincRNA gene expression suggest widespread RNA-independent functions“.
July 31, 2018
Today was Chiara’s last day in the lab. Good look for your third rotation in the course of the NCCR Predoc program!
Gizem also left us today after finishing her masters thesis. Good luck for your next steps!
July 17, 2018
Aparna just received the prestigious BiF PhD fellowship. Congrats!
May 24, 2018
New paper published in Nature on Adnp recruiting its partners Chd4 and HP1 in an H3K9me3-independent manner to euchromatin.
May 21, 2018
New review article on m6A RNA methylation published in FEBS Letters today!
Knuckles and Bühler, “Adenosine methylation as a molecular imprint defining the fate of RNA“.
May 14, 2018
Today, Marc was elected as EMBO Member! Congrats!
For older posts, see the news archive.
Marc Buhler | Marc Buehler | Marc Bühler | Buhler lab | Buehler lab | Bühler lab | FMI | Basel | Heterochromatin | Gene silencing | CoTGS | PTGS | TGS | RNAi | small RNA mediated silencing | small RNA mediated heterochromatin formation | ChAHP | ADNP | CHD4 | HP1