Research in our laboratory is focused on elucidating the function and evolutionary conservation of mechanisms that govern genome organization, chromatin structure and gene expression in eukaryotes.

news from the lab


July 9, 2021

We are back from the Corona depression!


July 6, 2021

Have a look at our new publication on further components involved in suppression of endogenous gene silencing by RNAi in S. pombe. Shimada Y, Carl SH, Skribbe M, Flury V, Kuzdere T, Kempf G, Bühler M. (2021). An enhancer screen identifies new suppressors of small-RNA-mediated epigenetic gene silencing.


July 1, 2021

Goodby and congrats to Max Louski who finished his masters thesis in our lab.

We welcome Jakob Schnabel coming from the Brennecke lab as a new postdoc in the lab!


June 30, 2021

Slightly delayed but nonetheless, we welcome Lauren Kane coming from the Bickmore lab as a new postdoc in the lab!


August 17, 2020

Looking for a method to deplete long non-coding RNAs (lincRNAs)? Alex wrote up a detailed protocol on how to use self-cleaving Ribozymes to specifically deplete lincRNA transcripts. Tuck A.C., Bühler M. (2021) Long Non-coding RNA Depletion Using Self-Cleaving Ribozymes. Methods in Molecular Biology. 


June 9, 2020

Fed up with manual yeast colony counting? Here is the solution: Carl SH, Duempelmann L, Shimada Y, Bühler M. A fully automated deep learning pipeline for high-throughput colony segmentation and classification. 2020. Biol open. 


May 20, 2020

Claudia Keller Valsecchi, a former PhD student of the Bühler lab, just started her own group at the IMB in Mainz. Check it out!


March 20, 2020

Today at 2pm Lea Duempelmann is defending her thesis but due to the current situation, sadly no audience is allowed. Therefore the defense talk will be streamed live via zoom and everybody interested can join in!

Topic: Inheritance of a phenotypically plastic epimutation

Zoom link:

Meeting ID: 716 618 113

Good luck, Lea!


February 27, 2020

Today was Aude’s last day after successfully defending her master thesis. All the best for your future and take care!

February 11, 2020

Alex and Aneliya’s paper on the interplay of RNA decay, RNA surveillance and translation is out now! Have a look here: Tuck AC*, Rankova A*, Arpat AB, Liechti LA, Hess D, Iesmantavicius V, Castelo-Szekely V, Gatfield D and Bühler M. Mammalian RNA decay pathways are highly specialized and widely linked to translation. 2020. Molecular Cell.

January 20, 2020

Want to learn more about where and how small RNAs are implicated in transgenerational epigenetic inheritance? Have a look at the review article by Lea and Merle that just came out.

Duempelmann L, Skribbe M, Bühler M. Small RNAs in the Transgenerational Inheritance of Epigenetic Information. 2020. Trends in Genetics.

October 14, 2019

Try our automated deep learning pipeline for yeast colony color classification. It speeds up white/red color quantification by 100-fold with very high accuracy, compared to manual counting by an experienced biologist. Any feedback or suggestions are welcome!


September 18-20, 2019

FMI annual meeting . We just spent three awesome days of science and mountaineering in Grindelwald.

Congrats to Alex, he received the Max Burger price for the best Postdoc paper in 2018!!!

September 5, 2019

New paper out in Cell on the role of the ChAHP (CHD4-ADNP-HP1) complex in 3D genome architecture and safe-guarding the genome against unwanted rewiring upon SINE-mediated CTCF motif expansions. Kaaij, Mohn et al. Cell, 2019.


August 18, 2019

New paper out in Genes & Development. Alex Tuck and Thomas Welte elucidated in a collaborative effort between the Bühler and Grosshans labs the role of the RNA binding protein Trim71 in normal and deseased states. Welte, Tuck et al., Genes Dev., 2019. 


March 27, 2019

New lab paper published in Molecular Cell! Duempelmann et al find an epimutation that is transmitted over generations without notable phenotype but will result in gene silencing when the Paf1 complex is mutated.


March 27, 2019

Finally it is time to get back to the bench after a sunny and powdery winter break 🙂 !

October 11, 2018

Our former PhD student Valentin Flury, together with Sivia Domcke, received this years Ed Fisher price awarded for the best thesis in 2017. Congrats!

September 19, 2018

We are looking for an enthusiastic bioinformatician to support our and Helge Grosshans lab. Interested? Have a look here and here job opening_grosshans_buehler_v5 A4 !

September 17, 2018

We welcome Merle Skribbe! Merle will conduct her masters thesis work in our lab. Good luck!

August 1, 2018

New lab paper comprehensively characterizing mouse lincRNAs is now online at Life Science Alliance. Tuck et al, “Distinctive features of lincRNA gene expression suggest widespread RNA-independent functions“.

July 31, 2018

Today was Chiara’s last day in the lab. Good look for your third rotation in the course of the NCCR Predoc program!

Gizem also left us today after finishing her masters thesis. Good luck for your next steps!

July 17, 2018

Aparna just received the prestigious BiF PhD fellowship. Congrats!

May 24, 2018

New paper published in Nature on Adnp recruiting its partners Chd4 and HP1 in an H3K9me3-independent manner to euchromatin.

Ostapcuk et al, “Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes

Screen Shot 2018-05-24 at 08.42.15

May 21, 2018

New review article on m6A RNA methylation published in FEBS Letters today!

Knuckles and Bühler, “Adenosine methylation as a molecular imprint defining the fate of RNA“.

May 14, 2018

Today, Marc was elected as EMBO Member! Congrats!


For older posts, see the news archive.




Marc Buhler | Marc Buehler | Marc Bühler | Buhler lab | Buehler lab | Bühler lab | FMI | Basel | Heterochromatin | Gene silencing | CoTGS | PTGS | TGS | RNAi | small RNA mediated silencing | small RNA mediated heterochromatin formation | ChAHP | ADNP | CHD4 | HP1

6 thoughts on “news from the lab

  1. Survival estimates for Primula vulgaris:


  2. estimated survival is longer then Trump will be the “president”…


  3. Still alive! We just have to keep watering them every day…


  4. Shabana Hanif 11. April 2019 — 7:22

    Hope you are doing well. I just visited web page of your lab and the work you are doing in impressive and of my intrest. I completed my M.Phil in Biochemistry and Molecular biology and looking for PhD. I just want to know your e.mail id.Will great full to you.


    1. Hi Shabana,

      thanks for your interest! Have a look at the ‘People’ section of the homepage, there you will find the email addresses associated with the names.


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