…..Welcome to the Bühler lab…..

It’s all about RNA(i), dude!

(…and maybe a bit about chromatin and 3D architecture…)

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We are located at the Friedrich Miescher Institute in Basel, Switzerland.

News from the lab:

October 14, 2019

Try our automated deep learning pipeline for yeast colony color classification. It speeds up white/red color quantification by 100-fold with very high accuracy, compared to manual counting by an experienced biologist. Any feedback or suggestions are welcome!


September 18-20, 2019

FMI annual meeting . We just spent three awesome days of science and mountaineering in Grindelwald.

Congrats to Alex, he received the Max Burger price for the best Postdoc paper in 2018!!!

September 5, 2019

New paper out in Cell on the role of the ChAHP (CHD4-ADNP-HP1) complex in 3D genome architecture and safe-guarding the genome against unwanted rewiring upon SINE-mediated CTCF motif expansions. Kaaij, Mohn et al. Cell, 2019.


August 18, 2019

New paper out in Genes & Development. Alex Tuck and Thomas Welte elucidated in a collaborative effort between the Bühler and Grosshans labs the role of the RNA binding protein Trim71 in normal and deseased states. Welte, Tuck et al., Genes Dev., 2019. 


March 27, 2019

New lab paper published in Molecular Cell! Duempelmann et al find an epimutation that is transmitted over generations without notable phenotype but will result in gene silencing when the Paf1 complex is mutated.


March 27, 2019

Finally it is time to get back to the bench after a sunny and powdery winter break 🙂 !

October 11, 2018

Our former PhD student Valentin Flury, together with Sivia Domcke, received this years Ed Fisher price awarded for the best thesis in 2017. Congrats!

September 19, 2018

We are looking for an enthusiastic bioinformatician to support our and Helge Grosshans lab. Interested? Have a look here and here job opening_grosshans_buehler_v5 A4 !

September 17, 2018

We welcome Merle Skribbe! Merle will conduct her masters thesis work in our lab. Good luck!

August 1, 2018

New lab paper comprehensively characterizing mouse lincRNAs is now online at Life Science Alliance. Tuck et al, “Distinctive features of lincRNA gene expression suggest widespread RNA-independent functions“.

July 31, 2018

Today was Chiara’s last day in the lab. Good look for your third rotation in the course of the NCCR Predoc program!

Gizem also left us today after finishing her masters thesis. Good luck for your next steps!

July 17, 2018

Aparna just received the prestigious BiF PhD fellowship. Congrats!

May 24, 2018

New paper published in Nature on Adnp recruiting its partners Chd4 and HP1 in an H3K9me3-independent manner to euchromatin.

Ostapcuk et al, “Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes

Screen Shot 2018-05-24 at 08.42.15

May 21, 2018

New review article on m6A RNA methylation published in FEBS Letters today!

Knuckles and Bühler, “Adenosine methylation as a molecular imprint defining the fate of RNA“.

May 14, 2018

Today, Marc was elected as EMBO Member! Congrats!

For older posts, see the news archive.


Marc Buhler | Marc Buehler | Marc Bühler | Buhler lab | Buehler lab | Bühler lab | FMI | Basel | Heterochromatin | Gene silencing | CoTGS | PTGS | TGS | RNAi | small RNA mediated silencing | small RNA mediated heterochromatin formation


6 thoughts on “…..Welcome to the Bühler lab…..

  1. Hi!
    Hope you are doing well. I just visited web page of your lab and the work you are doing in impressive and of my intrest. I completed my M.Phil in Biochemistry and Molecular biology and looking for PhD. I just want to know your e.mail id.Will great full to you.


    • Hi Shabana,

      thanks for your interest! Have a look at the ‘People’ section of the homepage, there you will find the email addresses associated with the names.


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